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Laboratorio di Gastroenterologia molecolare

Attività di Ricerca Luigi Laghi Pubblicazioni

PUBBLICAZIONI SELEZIONATE - dr. Luigi Laghi

  1. In vitro transcrition/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer. MC Luce, G Marra, DP Chauhan, L Laghi, JM Carethers, SP Cherian, M. Hawn, CG Binnie, LNW Kam Morgan, MC Cayouette, M Koi, CR Boland.  Gastroenterology 1995; 109:1368-1374
  2.   Cell-cycle dependent expression of human MutS homolog (hMSH2). G Marra, CL Chang, LA Laghi, DP Chauhan, D Young, CR Boland Oncogene 1996, 13:2189-2196
  3. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers.  Luigi Laghi, Ann E. Randolph, D.P. Chauhan, Gincarlo Marra, Eugene O. Major, James V. Neel, and C.Richard Boland.  Proceedings of the National Academy of Science USA .    1999; 96 (13): 7484-7489.
  4. JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Luigi Ricciardiello, Luigi Laghi, Pradeep Ramamirtham, Christina L. Chang, Dong K. Chang, Ann E. Randolph, and C. Richard Boland. Gastroenterology, 2000; 119: 1228-1235
  5. Lack of SRC 531 mutation in a consecutive series of advanced, late-stage and metastatic colorectal cancers.  Luigi Laghi , Paolo Bianchi, Ombretta Orbetegli, Leandro Gennari, Massimo Roncalli, Alberto Malesci. British Journal of Cancer, 2001; 84:196-198
  6. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Yashiro M, Carethers JM, Laghi L, Saito K, Slezak P, Jaramillo E, Rubio C, Koizumi K, Hirakawa K, and Boland CR.  Cancer Research, 2001; 61:2676-2683
  7. Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues. Ricciardiello L, Chang DK, Laghi L, Goel A, Chang CL, Boland CR. J Virol 2001;75:1996-2001
  8. Frameshift truncating mutations of the human gastrin receptor gene in gastrointestinal cancers with microsatellite instability.  Luigi Laghi , Guglielmina Nadia Ranzani, Paolo Bianchi, Antonio Mori, Karl Heinimann, Ombretta Orbetegli, Marco Rondo Spaudo, Massimo Roncalli, Enrico Solcia, and Alberto Malesci.  Laboratory Investigation, 2002; 82:265-271
  9. Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.  Luigi Laghi , Ombretta Orbetegli, Paolo Bianchi, Luisella Arborati, Alessandro Zerbi, Valerio Di Carlo, C. Richard Boland, Alberto Malesci. Oncogene, 2002, 21:4301-4306 
  10. Constraints imposed by supercoiling upon in vitro amplification of polyomavirus DNA.  L. Laghi , A.E. Randolph, A. Malesci, C.R. Boland. Journal of General Virology;  2004; 85:3383-8.
  11. Revised Bethesda Guidlines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability. L. Laghi, P. Bianchi, M. Roncalli, A. Malesci. Journal of the National Cancer Institute.  2004; 15:1402-1403
  12. Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps. Yashiro M, Laghi L, Saito K, Carethers JM, Slezak P, Rubio C, Hirakawa K, Boland CR. Cancer Epidemiol Biomarkers Prev . 2005; 14:2253-6.
  13.   Reduced Likelihood of Metastases in Patients with Microsatellite-Unstable Colorectal Cancer. Alberto Malesci, Luigi Laghi, Paolo Bianchi, Gabriele Delconte, Ann Randolph, Valter Torri, Carlo Carnaghi, Roberto Doci, Riccardo Rosati, Marco Montorsi, Massimo Roncalli, Leandro Gennari, Armando Santoro. Clin Cancer Res , 2007; 13: 3831-39
  14. Gullo L, Laghi L, Migliori M, Lucrezio L, Bianchi P, Randolph AE, Mantovani V, Bastagli L, Pezzilli R, Malesci A. SPINK1 and PRSS1 mutations in benign pancreatic hyperenzymemia. Pancreas. 2008;37:31-5
  15. Laghi L, Bianchi P, Malesci A.  Differences and evolution of the methods for the assessment of microsatellite instability. Oncogene. 2008 Aug 4. [Epub ahead of print]

PUBBLICAZIONI SELEZIONATE - dr. Paolo Bianchi

  1. Fractional allelic loss in non end-stage cirrhosis: correlation with hepatocellular carcinoma development during follow-up.  M. Roncalli, P. Bianchi, G. Ceva Grimaldi, D. Ricci, L. Laghi, M. Maggioni, E. Opocher, M. Borzio And G. Coggi.  Hepatology, 2000; 31:846-850
  2. Lack of SRC 531 mutation in a consecutive series of advanced, late-stage and metastatic colorectal cancers.  Luigi Laghi, Paolo Bianchi, Ombretta Orbetegli, Leandro Gennari, Massimo Roncalli, Alberto Malesci. British Journal of Cancer, 2001; 84:196-198
  3. Frameshift truncating mutations of the human gastrin receptor gene in gastrointestinal cancers with microsatellite instability.  Luigi Laghi, Guglielmina Nadia Ranzani, Paolo Bianchi, Antonio Mori, Karl Heinimann, Ombretta Orbetegli, Marco Rondo Spaudo, Massimo Roncalli, Enrico Solcia, and Alberto Malesci.  Laboratory Investigation, 2002; 82:265-271
  4. Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.  Luigi Laghi, Ombretta Orbetegli, Paolo Bianchi, Luisella Arborati, Alessandro Zerbi, Valerio Di Carlo, C. Richard Boland, Alberto Malesci. Oncogene, 2002, 21:4301-4306 
  5. Cell cycle gene inhibitors methylation framework in liver cirrhosis and associated hepatocellular carcinoma. Roncalli M., Bianchi P., Bruni B., Laghi L., Destro A., Gennari L., Tommasini M., Malesci A., Coggi G. Hepatology , 2002; 36:427-432
  6. Gender difference for promoter methylation pattern of hMLH1 and p16 in sporadic MSI colorectal cancer. Laghi L, Bianchi P, Malesci A. Gastroenterology. 2003; 124:1165-6
  7. Revised Bethesda Guidlines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability. L. Laghi, P. Bianchi, M. Roncalli, A. Malesci. Journal of the National Cancer Institute.  2004; 15:1402-1403 (Letter)
  8. Carriage of CARD15 variants and smoking as risk factors for resective surgery in patients with Crohn's ileal disease. Laghi L, Costa S, Saibeni S, Bianchi P, Omodei P, Carrara A, Spina L, Contessini Avesani E, Vecchi M, DE Franchis R, Malesci A. Aliment Pharmacol Ther. 2005; 22:557-64.
  9. Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. Di Gioia S, Bianchi P, Destro A, Grizzi F, Malesci A, Laghi L, Levrero M, Morabito A, Roncalli M. BMC Cancer. 2006; 6:89.
  10. Genetic and epigenetic changes in primary metastatic and non-metastatic colorectal cancer. Miranda E, Destro A, Malesci A,Balladore E, Bianchi P, Baryshnikova E, Franchi G, Morenghi E, Laghi L , Gennari L, Roncalli M. British Journal of Cancer.2006; 95: 1101-1107
  11. Reduced Likelihood of Metastases in Patients with Microsatellite-Unstable Colorectal Cancer. Alberto Malesci, Luigi Laghi, Paolo Bianchi, Gabriele Delconte, Ann Randolph, Valter Torri, Carlo Carnaghi, Roberto Doci, Riccardo Rosati, Marco Montorsi, Massimo Roncalli, Leandro Gennari, Armando Santoro . Clin Cancer Res, 2007; 13: 3831-39
  12. Laghi L, Bianchi P, malesci A. Survival in Microsatellite-UnstableColorectal Cancer, Reply to Watanabe T et al. Clin Cancer Res, 2008; 14:2516
  13. Gullo L, Laghi L, Migliori M, Lucrezio L, Bianchi P, Randolph AE, Mantovani V, Bastagli L, Pezzilli R, Malesci A.  SPINK1 and PRSS1 mutations in benign pancreatic hyperenzymemia. Pancreas. 2008;37:31-5

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Istituto Clinico Humanitas - P.I. 10125410158
Autorizzazioni: Decreto Presidente Regione Lombardia n° 1906 del 18.04.1996 Direttore Sanitario: dott. Norberto Silvestri - Specialista in Igiene e Tecnica Ospedaliera. L'Istituto Clinico Humanitas è una struttura ospedaliera accreditata Joint Commission International.